Does 52 lbs weight loss sound good to you? With Retatrutide, it's possible!

A June 2023 study from the New England Journal of Medicine studied Retatrutide, a medication primarily used for type 2 diabetes that’s making great strides in helping people lose weight in Brookfield WI. Over 2 years, people lost 52 lbs steadily and without the typical plateau. Study participants worked with a professional medical team focused on diet and exercise while using Retatrutide.

Most participants lost approximately 50 lbs and had a 17.5% increase in weight loss. Some participants did as well as 25% weight loss and achieved some fantastic health benefits.

In fact, some doctors have called this medication a rival to bariatric surgery.

And we have some great news! WeighlessMD will participate in a follow-up study to confirm the results and safety. If you want to participate in this study, we are currently taking applications, so contact us for more information.

---

Let's Take A Look At How Retatrutide Works

Retatrutide is a medication first tested to help control type 2 diabetes. In the preliminary studies, participants lost weight and gained control over their type 2 diabetes.

The primary mechanism of Retatrutide is a GLP-1 mimic and receptor agonist. This hormone helps reduce glucagon, which helps reduce blood sugar. Having too much glucagon in your blood can cause health issues, including kidney damage, depression, and neuropathy. It also influences your feeling of being full, which can help you eat less food overall.

But Retatrutide goes further. Retatrutide is also a GIP receptor agonist. This hormone helps lower blood sugar and is most effective with a low- to moderate-sugar diet. Working with a nutritionist is critical when taking this medication, as many food products sneak in sugar and other unhealthy ingredients.

Finally, combining GLP-1, GIP, and glucagon receptor agonists helps boost metabolism. They work together to help you feel full faster and longer. Additionally, working together can help improve one’s overall metabolic health.

Counseling is strongly recommended while taking this medication to help monitor diet, symptoms, dosing and muscle mass. Weighless MD recommends bi-weekly or monthly counseling sessions to help you track body composition and measurements.

---

How Does Retatrutide Compare to Semaglutide and Tirzepatide?

There are numerous weight loss medications on the market. Many of them come and go as side effects emerge. The modern incarnations of weight loss drugs work with the body, mimicking natural hormones and enzymes within the body that greatly reduce side effects.

Medications like Semaglutide and Tirzepatide are effective. But they can be incomplete.

You’ve probably heard of the most common semaglutide Ozempic. Wegovy is another brand name. Semaglutide is approved for type 2 diabetics and is a GLP-1 receptor agonist. Studies have shown that it helps people achieve 14.9% more weight loss than just diet and exercise alone.

Tirzepatide, sold under the brands Mounjaro and Zepbound, is a GLP-1 and GIP receptor agonist. It works a little bit better to control blood sugar and appetite, which can increase the amount of weight loss and the speed of weight loss. Tirzepatide has been shown to increase weight loss by 15% to 22.5% among study participants.

And this is where Retatrutide will outshine both of them. With up to a 25% increased weight loss, preliminary studies show people lose weight quickly, boost their metabolism, and learn to moderate their blood sugar faster. Study participants working with medical professionals focus on proper diet to build the foundation of healthy eating. The faster weight loss and increased metabolism from Retatrutide means the medication can be used for a shorter period while gaining tremendous health benefits.

To sum up:

• Semaglutide (Ozempic, Wegovy) – Single mode of action – 14.9%
• Tirzepatide (Monjouro, Zepbound) – Dual mode of action – 15-22.5%
• Retatrutide – Triple mode of action – up to 25%

---

Side Effects of Retatrutide

Retatrutide has a pretty good track record of being tolerated well by the study participants. The vast majority of side effects were mild and included nausea, vomiting, diarrhea, and acid reflux. Preliminary studies show this is similar to other drugs in the same classification. By working with a health professional, like WeighlessMD, you can lower your chances of having side effects or adjusting the dosage to mitigate the effects.

Those who have certain predispositions towards pancreatitis, gallbladder disease, or diabetic eye conditions should use caution, as it has contributed to causing or making these conditions worse. Additionally, people predisposed to medullary thyroid cancer or endocrine neoplasia type 2 should not take this medication at all.

Retatrutide has a fantastic track record for helping people lose weight with minimal to no side effects when working with your medical care team. Although it still needs to be confirmed in the study, using an appropriate diet from a nutritionist or dietitian helps reduce the chances of side effects.

The US FDA is aware of counterfeit products being sold without a prescription. In their report, many of the tested products do not contain any active ingredients and may contain dangerous other chemicals. The FDA strongly recommends that only a prescription be obtained through an approved medical office.

---

Join Us!

Fortunately, WeighlessMD is an approved office and will participate in one of the pivotal studies in 2025! Currently, we are seeking applicants who are interested in this weight loss program and will fit the study's criteria. If you are interested, we recommend contacting our office.

We will work with you to find the appropriate dosage of medication and the proper diet that fits your dietary needs and lifestyle, and work with you to maintain proper exercise and lifestyle habits that can accelerate your weight loss. Additionally, we'll work with you so you can maintain your weight loss in the long term.

Using a medication like Retatrutide can help accelerate your weight loss, especially paired with the accountability of a medical team that focuses on your overall health, including diet and exercise. Taking any weight loss medication alone will not achieve the results you're looking for, which is why we at WeighlessMD want to work with you to improve your total health.

---

References:

1. Jastreboff AM, Kaplan LM, Frías JP, et al. Triple–hormone-receptor agonist retatrutide for obesity — A phase 2 trial. N Engl J Med. 2023;389(6):514-526. doi:10.1056/nejmoa2301972
2. Learn more. Retatrutide weight loss: Can it rival bariatric surgery? Joinfound.com. Accessed December 23, 2024. https://joinfound.com/blog/retatrutide-weight-loss
3. FDA's Concerns with Unapproved GLP-1 Drugs Used for weight loss. U.S. Food and Drug Administration. December 18, 2024. Accessed December 23, 2024. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss
4. Naeem M, Imran L, Banatwala UESS. Unleashing the power of retatrutide: A possible triumph over obesity and overweight: A correspondence. Health Sci Rep. 2024 Feb 5;7(2):e1864. doi: 10.1002/hsr2.1864. PMID: 38323122; PMCID: PMC10844714.